Important Safety Considerations Before Taking Sildenafil

Splenda Alters Gut Microflora and Increases Intestinal P-Glycoprotein and Cytochrome P-450 in Male Rats. Journal of Toxicology and Environmental Health, Part A, 71(21), 1415–1429.

Tadalafil (the active ingredient in Cialis)

Potential role of the common food additive manufactured citric acid in eliciting significant inflammatory reactions contributing to serious disease states: A series of four case reports. Magnesium stearate, a widely-used food additive, exhibits a lack of in vitro and in vivo genotoxic potential. The Effects of Natural and Synthetic Blue Dyes on Human Health: A Review of Current Knowledge and Therapeutic Perspectives. Xylitol: A Review on Bioproduction, Application, Health Benefits, and Related Safety Issues. Critical Reviews in Food Science and Nutrition, 55(11), 1514–1528. Toxicological effects of Mentha x piperita (peppermint): a review. Phosphodiesterase-5 (PDE-5) Inhibitors and Ototoxicity: A Systematic Review. Whether Adding Vitamin D to Tadalafil 5 mg Treatment Is Useful in Patients with Erectile Dysfunction and Vitamin D Deficiency?

• Sildenafil increases blood flow to improve erectile function.
• Chewing sildenafil could potentially cause an overdose risk.
• Take sildenafil approximately 30-60 minutes before activity.
• Sildenafil isn't a cure for erectile dysfunction but helps manage symptoms.
• Do not chew or crush sildenafil tablets unless directed.
• Inform your doctor about underlying health conditions before use.
• Sildenafil may be less effective if taken with high-fat meals.
• Use sildenafil only if you have been diagnosed with ED.
• Report any severe side effects to your healthcare provider promptly.

Folic acid supplementation improves erectile function in patients with idiopathic vasculogenic erectile dysfunction by lowering peripheral and penile homocysteine plasma levels: a case-control study. Applies to sildenafil: oral powder for suspension, oral suspension, oral tablet. If you take sildenafil for pulmonary arterial hypertension, do not take Viagra® or other PDE5 inhibitors, including tadalafil (Cialis®) or vardenafil (Levitra®). Sildenafil should not be used with any other medicine or device that causes erections.

Some side effects of sildenafil may occur that usually do not need medical attention.

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Folic acid supplementation improves erectile function in patients with idiopathic vasculogenic erectile dysfunction by lowering peripheral and penile homocysteine plasma levels: a case-control study. Applies to sildenafil: oral powder for suspension, oral suspension, oral tablet. If you take sildenafil for pulmonary arterial hypertension, do not take Viagra® or other PDE5 inhibitors, including tadalafil (Cialis®) or vardenafil (Levitra®). Sildenafil should not be used with any other medicine or device that causes erections. Some side effects of sildenafil may occur that usually do not need medical attention.

Recreational use

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: pain or tenderness around the eyes and cheekbones diarrhea or stomach cramps (severe or continuing) numbness or tingling of the hands, legs, or feet redness, soreness, swelling, or bleeding of the gums sensation of motion, usually whirling, either of one's self or of one's surroundings sexual problems in men (continuing), including failure to experience a sexual orgasm sores in the mouth and on the lips Along with its needed effects, sildenafil may cause some unwanted effects. Check with your doctor immediately if any of the following side effects occur while taking sildenafil: burning feeling in the chest or stomach burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings decrease in amount of urine or the frequency of urination dizziness or lightheadedness, especially when getting up suddenly from a lying or sitting position dryness, redness, lovegra sildenafil scaling, or peeling of the skin increase in the size of the pupil redness, burning, or swelling of the eyes redness, itching, or tearing of the eyes seeing shades of colors differently than before swelling of the face, hands, feet, or lower legs unusual feeling of burning or stinging of the skin Applies to sildenafil: intravenous solution, oral film, oral powder for reconstitution, oral tablet. The most common adverse reactions occurring in patients with erectile dysfunction (ED) and pulmonary arterial hypertension (PAH) included headache, flushing, dyspepsia, abnormal vision, nasal congestion, back pain, myalgia, nausea, dizziness, rash, visual disturbance, cyanopsia, blurred vision, limb pain, priapism, upper respiratory infection, vomiting, bronchitis, pharyngitis, pyrexia, diarrhea, influenza, epistaxis. Very common (10% or more): Flushing (up to 19%) Rare (0.01% to 0.1%): Myocardial infarction, atrial fibrillation, unstable angina, tachycardia, palpitations Frequency not reported: Shock, angina pectoris, AV block, migraine, syncope, hypotension, postural hypotension, myocardial ischemia, cerebral thrombosis, cardiac arrest, heart failure, abnormal electrocardiogram, cardiomyopathy, vasodilation, abnormal electrocardiogram, increased heart rate Postmarketing reports: Myocardial infarction, sudden cardiac death, cardiac arrest, ventricular arrhythmia, hypertension, hypotensive events after the use with alpha-blockers, tachycardia, hypotension, syncope Very common (10% or more): Dyspepsia (up to 17%), diarrhea Common (1% to 10%): Nausea, vomiting, dry mouth, gastritis, gastroesophageal reflux disease, hemorrhoids, abdominal distension Rare (less than 0.1%): Oral hypoesthesia Frequency not reported: Glossitis, colitis, dysphagia, gastroenteritis, esophagitis, stomatitis, gingivitis Very common (10% or more): Pain in limb (up to 15%), myalgia (up to 14%), back pain (up to 13%) Frequency not reported: Arthritis, arthrosis, myalgia, tendon rupture, tenosynovitis, bone pain, myasthenia, synovitis Postmarketing reports: Pain in extremity, pain in jaw, arthralgia Very common (10% or more): Headache (up to 28% in ED; up to 49% in PAH) Common (1% to 10%): Dizziness, vertigo, paresthesia, tremor, burning sensation, migraine, hypoesthesia Rare (0.01% to 0.1%): Cerebrovascular accident, transient ischemic attack, syncope Frequency not reported: Ataxia, hypertonia, neuralgia, neuropathy, vertigo, depression, decreased reflexes/hyporeflexia, cerebral thrombosis, convulsion Postmarketing reports: Cerebrovascular hemorrhage, transient ischemic attack, subarachnoid hemorrhage, intracerebral hemorrhage, seizure, seizure recurrence, transient global amnesia Very common (10% or more): Abnormal vision (up to 11%) Common (1% to 10%): Abnormal sensation in eye, chromatopsia, cyanopsia, diplopia, eye irritation, photophobia, retinal hemorrhage, visual acuity reduced, visual color distortion Uncommon (0.1% to 1%): Dry eye, lacrimal disorder, photopsia, ocular hyperemia, visual brightness, conjunctivitis, eye pain Rare (0.01% to 0.1%): Arteriosclerotic retinopathy, retinal disorder, glaucoma, visual field defect, myopia, asthenopia, vitreous floaters, iris disorder, mydriasis, halo vision, eye edema, eye swelling, eye disorder, conjunctival hyperemia, eyelid edema, scleral discoloration Frequency not reported: Eye hemorrhage, cataract, visual disturbance, xanthopsia, erythropsia Postmarketing reports: Diplopia, temporary vision loss/decreased vision, ocular redness or bloodshot appearance, ocular burning, ocular swelling/pressure, increased intraocular pressure, retinal edema, retinal vascular disease or bleeding, vitreous traction/detachment, non-arteritic anterior ischemic optic neuropathy (NAION) Abnormal vision included a severity that was mild to moderate and transient, characterized predominantly by color tinge to vision, but also increased sensitivity to light, or blurred vision. Lacrimation disorders included dry eye, lacrimal disorder, and lacrimation increased. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: pain or tenderness around the eyes and cheekbones diarrhea or stomach cramps (severe or continuing) numbness or tingling of the hands, legs, or feet redness, soreness, swelling, or bleeding of the gums sensation of motion, usually whirling, either of one's self or of one's surroundings sexual problems in men (continuing), including failure to experience a sexual orgasm sores in the mouth and on the lips Along with its needed effects, sildenafil may cause some unwanted effects. Check with your doctor immediately if any of the following side effects occur while taking sildenafil: burning feeling in the chest or stomach burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings decrease in amount of urine or the frequency of urination dizziness or lightheadedness, especially when getting up suddenly from a lying or sitting position dryness, redness, lovegra sildenafil scaling, or peeling of the skin increase in the size of the pupil redness, burning, or swelling of the eyes redness, itching, or tearing of the eyes seeing shades of colors differently than before swelling of the face, hands, feet, or lower legs unusual feeling of burning or stinging of the skin Applies to sildenafil: intravenous solution, oral film, oral powder for reconstitution, oral tablet.

Side Effects

Splenda Alters Gut Microflora and Increases Intestinal P-Glycoprotein and Cytochrome P-450 in Male Rats. Journal of Toxicology and Environmental Health, Part A, 71(21), 1415–1429. Potential role of the common food additive manufactured citric acid in eliciting significant inflammatory reactions contributing to serious disease states: A series of four case reports. Magnesium stearate, a widely-used food additive, exhibits a lack of in vitro and in vivo genotoxic potential. The Effects of Natural and Synthetic Blue Dyes on Human Health: A Review of Current Knowledge and Therapeutic Perspectives.

How should I store sildenafil?

Xylitol: A Review on Bioproduction, Application, Health Benefits, and Related Safety Issues. Critical Reviews in Food Science and Nutrition, 55(11), 1514–1528. Toxicological effects of Mentha x piperita (peppermint): a review. Phosphodiesterase-5 (PDE-5) Inhibitors and Ototoxicity: A Systematic Review. Whether Adding Vitamin D to Tadalafil 5 mg Treatment Is Useful in Patients with Erectile Dysfunction and Vitamin D Deficiency? The most common adverse reactions occurring in patients with erectile dysfunction (ED) and pulmonary arterial hypertension (PAH) included headache, flushing, dyspepsia, abnormal vision, nasal congestion, back pain, myalgia, nausea, dizziness, rash, visual disturbance, cyanopsia, blurred vision, limb pain, priapism, upper respiratory infection, vomiting, bronchitis, pharyngitis, pyrexia, diarrhea, influenza, epistaxis. Very common (10% or more): Flushing (up to 19%) Rare (0.01% to 0.1%): Myocardial infarction, atrial fibrillation, unstable angina, tachycardia, palpitations Frequency not reported: Shock, angina pectoris, AV block, migraine, syncope, hypotension, postural hypotension, myocardial ischemia, cerebral thrombosis, cardiac arrest, heart failure, abnormal electrocardiogram, cardiomyopathy, vasodilation, abnormal electrocardiogram, increased heart rate Postmarketing reports: Myocardial infarction, sudden cardiac death, cardiac arrest, ventricular arrhythmia, hypertension, hypotensive events after the use with alpha-blockers, tachycardia, hypotension, syncope Very common (10% or more): Dyspepsia (up to 17%), diarrhea Common (1% to 10%): Nausea, vomiting, dry mouth, gastritis, gastroesophageal reflux disease, hemorrhoids, abdominal distension Rare (less than 0.1%): Oral hypoesthesia Frequency not reported: Glossitis, colitis, dysphagia, gastroenteritis, esophagitis, stomatitis, gingivitis Very common (10% or more): Pain in limb (up to 15%), myalgia (up to 14%), back pain (up to 13%) Frequency not reported: Arthritis, arthrosis, myalgia, tendon rupture, tenosynovitis, bone pain, myasthenia, synovitis Postmarketing reports: Pain in extremity, pain in jaw, arthralgia Very common (10% or more): Headache (up to 28% in ED; up to 49% in PAH) Common (1% to 10%): Dizziness, vertigo, paresthesia, tremor, burning sensation, migraine, hypoesthesia Rare (0.01% to 0.1%): Cerebrovascular accident, transient ischemic attack, syncope Frequency not reported: Ataxia, hypertonia, neuralgia, neuropathy, vertigo, depression, decreased reflexes/hyporeflexia, cerebral thrombosis, convulsion Postmarketing reports: Cerebrovascular hemorrhage, transient ischemic attack, subarachnoid hemorrhage, intracerebral hemorrhage, seizure, seizure recurrence, transient global amnesia Very common (10% or more): Abnormal vision (up to 11%) Common (1% to 10%): Abnormal sensation in eye, chromatopsia, cyanopsia, diplopia, eye irritation, photophobia, retinal hemorrhage, visual acuity reduced, visual color distortion Uncommon (0.1% to 1%): Dry eye, lacrimal disorder, photopsia, ocular hyperemia, visual brightness, conjunctivitis, eye pain Rare (0.01% to 0.1%): Arteriosclerotic retinopathy, retinal disorder, glaucoma, visual field defect, myopia, asthenopia, vitreous floaters, iris disorder, mydriasis, halo vision, eye edema, eye swelling, eye disorder, conjunctival hyperemia, eyelid edema, scleral discoloration Frequency not reported: Eye hemorrhage, cataract, visual disturbance, xanthopsia, erythropsia Postmarketing reports: Diplopia, temporary vision loss/decreased vision, ocular redness or bloodshot appearance, ocular burning, ocular swelling/pressure, increased intraocular pressure, retinal edema, retinal vascular disease or bleeding, vitreous traction/detachment, non-arteritic anterior ischemic optic neuropathy (NAION) Abnormal vision included a severity that was mild to moderate and transient, characterized predominantly by color tinge to vision, but also increased sensitivity to light, or blurred vision. Lacrimation disorders included dry eye, lacrimal disorder, and lacrimation increased.

• Sildenafil enhances natural erectile responses with proper use.
• Chewing sildenafil is discouraged because it may cause irritation.
• Follow dosing guidelines strictly to avoid complications.
• Sildenafil is effective but not a cure for all causes of ED.
• Take sildenafil at the same time each day if prescribed regularly.
• Be cautious about using sildenafil with concomitant medications.
• Keep sildenafil out of sun and moisture to preserve quality.
• Side effects may diminish over time with continued use.
• Always consult a healthcare provider for personalized advice.

Very common (10% or more): Upper respiratory tract infection (up to 31%), bronchitis (up to 20%), pharyngitis (up to 18%) Common (1% to 10%): Nasal congestion, cough, epistaxis, dyspnea, sinusitis, rhinitis, bronchitis, pneumonia, rhinorrhea Uncommon (0.1% to 1%): Sinus congestion Frequency not reported: Asthma, laryngitis, increased sputum, increased cough, respiratory tract infection, throat tightness, nasal dryness, nasal edema, bronchopneumonia, hypoxia, stridor, pulmonary hypertension Common (1% to 10%): Rash, erythema, alopecia Frequency not reported: Face edema, photosensitivity reaction, urticaria, pruritus, sweating, skin ulcer, contact dermatitis, exfoliative dermatitis Postmarketing reports: Stevens-Johnson syndrome (SJS), Toxic epidermal necrolysis (TEN) Postmarketing reports: Vaso-occlusive crisis (in patients with PAH secondary to sickle cell disease) Common (1% to 10%): Increased weight, fluid retention Frequency not reported: Edema, gout, unstable diabetes, hyperglycemia, peripheral edema, hyperuricemia, hypoglycemic reaction, hypernatremia Very common (10% or more): Pyrexia (up to 17%), influenza (up to 12%) Common (1% to 10%): Cellulitis, gynecomastia, breast enlargement, night sweats Uncommon (0.1% to 1%): Tinnitus, chest pain, feeling hot, fatigue Rare (0.01% to 0.1%): Deafness, irritability Frequency not reported: Asthenia, pain, chills, accidental fall, accidental injury, thirst, sudden decrease or loss of hearing, ear pain, flu syndrome, infection, herpes simplex Postmarketing reports: Sudden decrease or loss of hearing Common (1% to 10%): Increased erection, urinary tract infection Uncommon (0.1% to 1%): Penile hemorrhage, hematospermia Frequency not reported: Cystitis, nocturia, urinary frequency, urinary incontinence, abnormal ejaculation, genital edema, anorgasmia, prostatic disorder Pfizer U.S.

Common side effects of sildenafil

Erectile dysfunction

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Final Thoughts

Very common (10% or more): Upper respiratory tract infection (up to 31%), bronchitis (up to 20%), pharyngitis (up to 18%) Common (1% to 10%): Nasal congestion, cough, epistaxis, dyspnea, sinusitis, rhinitis, bronchitis, pneumonia, rhinorrhea Uncommon (0.1% to 1%): Sinus congestion Frequency not reported: Asthma, laryngitis, increased sputum, increased cough, respiratory tract infection, throat tightness, nasal dryness, nasal edema, bronchopneumonia, hypoxia, stridor, pulmonary hypertension Common (1% to 10%): Rash, erythema, alopecia Frequency not reported: Face edema, photosensitivity reaction, urticaria, pruritus, sweating, skin ulcer, contact dermatitis, exfoliative dermatitis Postmarketing reports: Stevens-Johnson syndrome (SJS), Toxic epidermal necrolysis (TEN) Postmarketing reports: Vaso-occlusive crisis (in patients with PAH secondary to sickle cell disease) Common (1% to 10%): Increased weight, fluid retention Frequency not reported: Edema, gout, unstable diabetes, hyperglycemia, peripheral edema, hyperuricemia, hypoglycemic reaction, hypernatremia Very common (10% or more): Pyrexia (up to 17%), influenza (up to 12%) Common (1% to 10%): Cellulitis, gynecomastia, breast enlargement, night sweats Uncommon (0.1% to 1%): Tinnitus, chest pain, feeling hot, fatigue Rare (0.01% to 0.1%): Deafness, irritability Frequency not reported: Asthenia, pain, chills, accidental fall, accidental injury, thirst, sudden decrease or loss of hearing, ear pain, flu syndrome, infection, herpes simplex Postmarketing reports: Sudden decrease or loss of hearing Common (1% to 10%): Increased erection, urinary tract infection Uncommon (0.1% to 1%): Penile hemorrhage, hematospermia Frequency not reported: Cystitis, nocturia, urinary frequency, urinary incontinence, abnormal ejaculation, genital edema, anorgasmia, prostatic disorder Pfizer U.S. Pharmaceuticals Group, SUPPL-25 Cialis vs Viagra - What's the difference between them? Do you know these 11 amazing facts sildenafil generic about Viagra? Is generic Viagra available in the U.S.? Sildenafil side effects can vary depending on the individual.

Professional resources

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide. Our friendly customer care team is standing by for support. This content is intended for counseling purposes only. Is generic Viagra available in the U.S.? Sildenafil side effects can vary depending on the individual.

Before Using

This content is informational/educational and is not intended to treat or diagnose any disease or patient. No claims are made as to the safety or efficacy of mentioned preparations. The compounded medications featured in this content have been prescribed and/or administered by prescribers who work with Wedgewood Pharmacy. You are encouraged to speak with your prescriber as to the appropriate use of any medication. Wedgewood Pharmacy's compounded veterinary preparations are not intended for use in food and food-producing animals.

Missed Dose

All product and company names are trademarks™ or registered® trademarks of their respective holders. Use of them does not imply any affiliation with or endorsement by them. Spontaneous sex for less than $2/day Thinking of increasing your sildenafil dosage on your own for even longer, harder erections? Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide. Our friendly customer care team is standing by for support. This content is intended for counseling purposes only.

This content is informational/educational and is not intended to treat or diagnose any disease or patient. No claims are made as to the safety or efficacy of mentioned preparations. The compounded medications featured in this content have been prescribed and/or administered by prescribers who work with Wedgewood Pharmacy.

• Sildenafil is a medication used primarily to treat erectile dysfunction.
• Chewing sildenafil can alter how quickly it takes effect.
• Swallowing sildenafil whole is recommended for proper absorption.
• Chewing sildenafil may lead to unpredictable drug absorption.
• Sildenafil should be taken with water, ideally on an empty stomach.
• Altering the form of sildenafil can increase the risk of side effects.
• The standard dose of sildenafil varies from 25mg to 100mg.
• Consult a healthcare provider before modifying sildenafil intake.
• Do not chew sildenafil if it is in its original tablet form.

You are encouraged to speak with your prescriber as to the appropriate use of any medication. Wedgewood Pharmacy's compounded veterinary preparations are not intended for use in food and food-producing animals. All product and company names are trademarks™ or registered® trademarks of their respective holders. Use of them does not imply any affiliation with or endorsement by them.

• Sildenafil works by relaxing blood vessels in the penis.
• Chewing sildenafil might cause a faster onset of action.
• Crushing sildenafil tablets can affect its efficacy and safety.
• Sildenafil is not meant to be chewed, broken, or crushed.
• Use sildenafil as directed by a doctor for optimal results.
• Be aware that chewing sildenafil can increase side effects.
• Sildenafil is available by prescription only in many countries.
• Avoid taking sildenafil with heavy meals or high-fat foods.
• Inform your doctor of any medications you are taking before using sildenafil.

Spontaneous sex for less than $2/day Thinking of increasing your sildenafil dosage on your own for even longer, harder erections?