How Neurotransmitters Influence Sexual Response

As you can see, Cake’s prescription products can’t be purchased on a one-time basis.

This means that you’ll have to sign up for a recurring subscription if you’re interested in either of those. Drive For Her, on the other hand, can be purchased either way, and it’s covered under the company’s 30-day satisfaction guarantee. Around 100 treatments per bottle if used as directed Peppermint oil and damiana may promote arousal Should be safe for pregnant individuals (still check with your doctor, though) Not recommended for people with genital herpes due to L-arginine content No guarantee available and refunds are only for unopened products Some people may not like the warming, yet cold and minty sensation Unbound (also known as “Unbound Babes”) is a sexual wellness company that is, in its own words, “dedicated to demystifying an often overwhelming and intimidating shopping experience by providing educational content and well-designed, affordable, body-safe products.” While the brand offers quite a large selection of items, our focus for this guide is on Unbound’s water-based arousal gel, Jolt Gel.

Episode Transcript

However, as with all of the supplements mentioned in this guide, the potential effects will take time to appear — anywhere from a few weeks to a couple of months. Unlike the other options in our top picks, there’s a strange lack of transparency with some of the ingredients in the HerSolution supplement. On the Leading Edge Health website, the company lists the “HerSolution formula” as: This formula is further described as “a blend of herbals, amino acids, aphrodisiacs, and sexual nutrients.” We’re not entirely sure what a “sexual nutrient” is, but we do know that while the formula is, indeed, herbals and some other botanical ingredients used as aphrodisiacs, there aren’t any amino acids in HerSolution. Niacin (or nicotinic acid) can come from an amino acid, tryptophan, but it isn’t one itself — and that’s the closest thing we could find.31 But that’s not where the transparency issue lies; the main problem we have with HerSolution is Leading Edge Health’s confusing decision not to mention that this supplement contains two synthetic hormones: melatonin (5mg) and DHEA (25mg). The former isn’t the worst addition in the world (it may cause daytime sleepiness and headaches), but the latter can have serious health consequences; DHEA is not studied nearly enough to be worth an inclusion without mention.32 The amount of DHEA in HerSolution falls under the “possibly safe” category if you use the supplement as directed, and the other ingredients are all generally safe (with some decent scientific backing for helping sexual dysfunction), but an ingredient that the Mayo Clinic suggests avoiding seems worth a section on the product page.5 6 To be clear, we’re not saying that you shouldn’t try HerSolution if it sounds like something you’re interested in — it very well may be the most helpful option for you, and you should discuss it with your doctor.

A note about sex and gender

We just want to properly inform you of the potential risks associated with the supplement since Leading Edge Health doesn’t try to. Interact with prescription medications (particularly those for mental health, including SSRIs, antipsychotics, carbamazepine, lithium, and valproic acid) Worsen psychiatric disorders and increase the risk of mania in people with mood disorders Increase the risk of hormone-sensitive cancers (prostate, breast, and ovarian) Lead to oily skin, acne, or hirsutism in women (male-pattern hair growth) For more information on the potential drug interactions, you can find extensive lists from the Mayo Clinic and Mount Sinai. In terms of potential benefits of DHEA, the synthetic hormone may improve sex drive in older, postmenopausal women, specifically (not younger, premenopausal women). The results have been mixed, however.12 Looking at the rest of the ingredients, the outlook for trying HerSolution is a bit more positive. While we delve further into the nitty gritty details of these ingredients in our full HerSolution review, the following list breaks down some of the research. Cream and Cake Meds’ O-Cream Rx, Jolt Gel doesn’t contain any medications. Instead, this over-the-counter gel’s star ingredients are: L-Arginine and peppermint oil (due to its menthol content) can both promote increased blood flow through vasodilation.49 51 And damiana, or Turnera diffusa, is considered an aphrodisiac in traditional medicine.52 Studies are limited, but damiana appeared to help “sexually exhausted male rats” recover sexual behavior in a 2009 study.53 Of course, more research — especially on humans — is needed before we can definitively say damiana is effective. The other amino acid in the gel, L-ornithine, doesn’t have much research on it as a topical treatment, but it does appear to have some potential as a stress hormone reducer (for cortisol, specifically) when supplemented orally.50 But, as mentioned with damiana, more research is needed. Additionally, it’s important to note that Jolt Gel is not recommended for those with genital herpes, as the L-arginine content can trigger a flare-up. Jolt Gel can be purchased for $24 per bottle ($0.24 per pea-sized dose) either directly from Unbound or from its official Amazon storefront. At this time, we recommend purchasing through Amazon, as Unbound’s website doesn’t currently offer subscriptions. Even though Amazon’s subscription option, unfortunately, doesn’t come with a discount, it does let you receive regular shipments of Jolt Gel without having to remember to reorder. Additionally, throughout our time keeping an eye on these products, we found that the Jolt Gel on Amazon goes on sale rather frequently. For example, at one point in early 2025, it was only $16.80 per bottle — that’s 30% off the regular price. But by the end of 2025 and heading into 2026, the price has returned to $24. Neither purchase avenue accepts returns or refunds of opened products, but Unbound will accept returns of unopened, unused Jolt Gel within 30 days of purchase. Amazon, in contrast, won’t accept returns at all for safety reasons. This no-return policy isn’t that out tadacip 20mg of the ordinary; it’s similar to the policies of Wisp and Cake Meds for their topical arousal products.

Should be generally safe for healthy adults when used as directed Several ingredients have research suggesting potential efficacy Company fails to mention inclusion of melatonin and potentially risky DHEA Unsafe for those who are pregnant or breastfeeding DHEA may interact with medications, worsen mental health, and raise risk of mania Money-back guarantee requires minimum purchase of 2-month supply Potential results take at least a few weeks to months HerSolution is a female libido support supplement from the wellness company Leading Edge Health. Like VitaFLUX, it’s intended to help women and AFAB individuals with sexual dysfunction symptoms, like vaginal dryness, difficulty achieving orgasm, and low sex drive. This one-pill, once-a-day supplement may be more appealing to some who don’t wish to take six VitaFLUX capsules. However, as with all of the supplements mentioned in this guide, the potential effects will take time to appear — anywhere from a few weeks to a couple of months.

Further information

Niacin: Can improve blood flow via the promotion of nitric oxide production.33 Hops extract: May help relieve hot flashes and increase libido via its potential to bind to estrogen receptors.34 35 Mucuna pruriens: Contains a precursor to dopamine, one of the neurotransmitters heavily involved in sexual arousal.17 36 Tribulus terrestris: “Significantly improved” postmenopausal patients' levels of desire and arousal, along with promoting orgasms and reducing pain from intercourse in one 2016 study. (And the dose in this study was 750mg per day compared to the 150mg in HerSolution. Ginkgo biloba: Can influence nitric oxide production.38 Epimedium sagittatum: Might increase sexual desire in postmenopausal women by promoting estrogen biosynthesis.39 Cayenne pepper: Acts as a vasodilator and can promote the release of nitric oxide.40 Melatonin: May improve sexual function in postmenopausal women.41 You can purchase HerSolution directly from Leading Edge Health, on either the company’s website or the product’s dedicated site (both are legitimate). Buying more than a one-month supply also gets you a free tube of HerSolution Gel, which retails for $59 (we discuss the gel in more detail later on). Here’s how the cost of HerSolution breaks down: Depending on whether you purchase from Leading Edge Health or from the HerSolution website, the shipping costs will differ.

Emotional And Psychological Factors

You always cenforce 100mg tablet need to pay for shipping from the former, but the latter only charges shipping if you purchase a 1-month supply; bulk orders ship free. The different prices are noted in the lists below. USPS standard 7-14 day: $5.99 And because it can take a few weeks to see results, Leading Edge Health suggests trying the product for at least 60 days. If you’re not satisfied, you can take advantage of the company’s 67-day money-back guarantee. Promescent and Wisp, in comparison, also have set lengths for their guarantees but they don’t require you to wait any specific amount of time. Unlike the other options in our top picks, there’s a strange lack of transparency with some of the ingredients in the HerSolution supplement.

Related topics

Insider Tip: You’ll need to buy at least a 2-month supply of HerSolution to be eligible for the money-back guarantee. Unfortunately, the company doesn’t make this well known, but the policy notes that all returns should have “two-opened containers” — meaning you purchased two and tried the product for 60 days. Of course, nothing is stopping you from trying it, stopping it if you don’t like it, and still sending in those empty containers for your money back after the 60 days are up. Mostly-botanical formula should be safe for sensitive skin Can be used as an arousal gel and personal lubricant L-arginine can trigger herpes flare-ups A separate product from the pill for low libido that bears the same name, HerSolution Gel may help with some of the physical issues associated with arousal. This water-based gel can be used to increase vaginal lubrication and promote physical arousal through the inclusion of L-arginine.

Is it safe?

The active ingredients in HerSolution Gel include: L-arginine, a precursor of nitric oxide, may help dilate blood vessels and stimulate blood flow.10 Aloe, shea, and cocoa butter can provide additional vaginal lubrication. On the Leading Edge Health website, the company lists the “HerSolution formula” as: This formula is further described as “a blend of herbals, amino acids, aphrodisiacs, and sexual nutrients.” We’re not entirely sure what a “sexual nutrient” is, but we do know that while the formula is, indeed, herbals and some other botanical ingredients used as aphrodisiacs, there aren’t any amino acids in HerSolution. Niacin (or nicotinic acid) can come from an amino acid, tryptophan, but it isn’t one itself — and that’s the closest thing we could find.31 But that’s not where the transparency issue lies; the main problem we have with HerSolution is Leading Edge Health’s confusing decision not to mention that this supplement contains two synthetic hormones: melatonin (5mg) and DHEA (25mg). The former isn’t the worst addition in the world (it may cause daytime sleepiness and headaches), but the latter can have serious health consequences; DHEA is not studied nearly enough to be worth an inclusion without mention.32 The amount of DHEA in HerSolution falls under the “possibly safe” category if you use the supplement as directed, and the other ingredients are all generally safe (with some decent scientific backing for helping sexual dysfunction), but an ingredient that the Mayo Clinic suggests avoiding seems worth a section on the product page.5 6 To be clear, we’re not saying that you shouldn’t try HerSolution if it sounds like something you’re interested in — it very well may be the most helpful option for you, and you should discuss it with your doctor.

• Sildenafil (Viagra) can increase blood flow, potentially boosting arousal.
• Tadalafil (Cialis) works longer, providing hours of improved mood and desire.
• Levitra (Vardenafil) may help enhance sensitivity and desire quickly.
• Injectables like alprostadil increase blood flow instantly for arousal.
• Herbal supplements like ginseng are believed to boost energy and mood.
• OTC products claim to enhance libido through various ingredients.

We just want to properly inform you of the potential risks associated with the supplement since Leading Edge Health doesn’t try to.

Interact with prescription medications (particularly those for mental health, including SSRIs, antipsychotics, carbamazepine, lithium, and valproic acid) Worsen psychiatric disorders and increase the risk of mania in people with mood disorders Increase the risk of hormone-sensitive cancers (prostate, breast, and ovarian) Lead to oily skin, acne, or hirsutism in women (male-pattern hair growth) For more information on the potential drug interactions, you can find extensive lists from the Mayo Clinic and Mount Sinai. In terms of potential benefits of DHEA, the synthetic hormone may improve sex drive in older, postmenopausal women, specifically (not younger, premenopausal women). The results have been mixed, however.12 Looking at the rest of the ingredients, the outlook for trying HerSolution is a bit more positive.

Similar questions

As you can see, Cake’s prescription products can’t be purchased on a one-time basis. This means that you’ll have to sign up for a recurring subscription if you’re interested in either of those. Drive For Her, on the other hand, can be purchased either way, and it’s covered under the company’s 30-day satisfaction guarantee. Around 100 treatments per bottle if used as directed Peppermint oil and damiana may promote arousal Should be safe for pregnant individuals (still check with your doctor, though) Not recommended for people with genital herpes due to L-arginine content No guarantee available and refunds are only for unopened products Some people may not like the warming, yet cold and minty sensation Unbound (also known as “Unbound Babes”) is a sexual wellness company that is, in its own words, “dedicated to demystifying an often overwhelming and intimidating shopping experience by providing educational content and well-designed, affordable, body-safe products.” While the brand offers quite a large selection of items, our focus for this guide is on Unbound’s water-based arousal gel, Jolt Gel. Cream and Cake Meds’ O-Cream Rx, Jolt Gel doesn’t contain any medications.

Libido Pills For Women At Hello Cake

Instead, this over-the-counter gel’s star ingredients are: L-Arginine and peppermint oil (due to its menthol content) can both promote increased blood flow through vasodilation.49 51 And damiana, or Turnera diffusa, is considered an aphrodisiac in traditional medicine.52 Studies are limited, but damiana appeared to help “sexually exhausted male rats” recover sexual behavior in a 2009 study.53 Of course, more research — especially on humans — is needed before we can definitively say damiana is effective. The other amino acid in the gel, L-ornithine, doesn’t have much research on it as a topical treatment, but it does appear to have some potential as a stress hormone reducer (for cortisol, specifically) when supplemented orally.50 But, as mentioned with damiana, more research is needed. Additionally, it’s important to note that Jolt Gel is not recommended for those with genital herpes, as the L-arginine content can trigger a flare-up. Jolt Gel can be purchased for $24 per bottle ($0.24 per pea-sized dose) either directly from Unbound or from its official Amazon storefront. At this time, we recommend purchasing through Amazon, as Unbound’s website doesn’t currently offer subscriptions. While we delve further into the nitty gritty details of these ingredients in our full HerSolution review, the following list breaks down some of the research. Niacin: Can improve blood flow via the promotion of nitric oxide production.33 Hops extract: May help relieve hot flashes and increase libido via its potential to bind to estrogen receptors.34 35 Mucuna pruriens: Contains a precursor to dopamine, one of the neurotransmitters heavily involved in sexual arousal.17 36 Tribulus terrestris: “Significantly improved” postmenopausal patients' levels of desire and arousal, along with promoting orgasms and reducing pain from intercourse in one 2016 study.

• Black cohosh is sometimes used to increase libido temporarily.
• Yohimbine is a supplement linked to improved blood flow and desire.
• Maca root is popular for boosting energy and sexual desire swiftly.
• Ginkgo biloba is thought to improve circulation and arousal quickly.
• Damiana herb is traditionally used as an aphrodisiac for immediate effect.
• Horny goat weed may support increased arousal within an hour.

(And the dose in this study was 750mg per day compared to the 150mg in HerSolution.

Side Effects and Risks

Even though Amazon’s subscription option, unfortunately, doesn’t come with a discount, it does let you receive regular shipments of Jolt Gel without having to remember to reorder. Additionally, throughout our time keeping an eye on these products, we found that the Jolt Gel on Amazon goes on sale rather frequently. For example, at one point in early 2025, it was only $16.80 per bottle — that’s 30% off the regular price. But by the end of 2025 and heading into 2026, the price has returned to $24. Neither purchase avenue accepts returns or refunds of opened products, but Unbound will accept returns of unopened, unused Jolt Gel within 30 days of purchase.

Psychological causes

Amazon, in contrast, won’t accept returns at all for safety reasons. This no-return policy isn’t that out tadacip 20mg of the ordinary; it’s similar to the policies of Wisp and Cake Meds for their topical arousal products. Should be generally safe for healthy adults when used as directed Several ingredients have research suggesting potential efficacy Company fails to mention inclusion of melatonin and potentially risky DHEA Unsafe for those who are pregnant or breastfeeding DHEA may interact with medications, worsen mental health, and raise risk of mania Money-back guarantee requires minimum purchase of 2-month supply Potential results take at least a few weeks to months HerSolution is a female libido support supplement from the wellness company Leading Edge Health. Like VitaFLUX, it’s intended to help women and AFAB individuals with sexual dysfunction symptoms, like vaginal dryness, difficulty achieving orgasm, and low sex drive. This one-pill, once-a-day supplement may be more appealing to some who don’t wish to take six VitaFLUX capsules. Ginkgo biloba: Can influence nitric oxide production.38 Epimedium sagittatum: Might increase sexual desire in postmenopausal women by promoting estrogen biosynthesis.39 Cayenne pepper: Acts as a vasodilator and can promote the release of nitric oxide.40 Melatonin: May improve sexual function in postmenopausal women.41 You can purchase HerSolution directly from Leading Edge Health, on either the company’s website or the product’s dedicated site (both are legitimate). Buying more than a one-month supply also gets you a free tube of HerSolution Gel, which retails for $59 (we discuss the gel in more detail later on). Here’s how the cost of HerSolution breaks down: Depending on whether you purchase from Leading Edge Health or from the HerSolution website, the shipping costs will differ. You always cenforce 100mg tablet need to pay for shipping from the former, but the latter only charges shipping if you purchase a 1-month supply; bulk orders ship free. The different prices are noted in the lists below. USPS standard 7-14 day: $5.99 And because it can take a few weeks to see results, Leading Edge Health suggests trying the product for at least 60 days. If you’re not satisfied, you can take advantage of the company’s 67-day money-back guarantee.

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Vyleesi (bremelanotide)

Promescent and Wisp, in comparison, also have set lengths for their guarantees but they don’t require you to wait any specific amount of time. Insider Tip: You’ll need to buy at least a 2-month supply of HerSolution to be eligible for the money-back guarantee. Unfortunately, the company doesn’t make this well known, but the policy notes that all returns should have “two-opened containers” — meaning you purchased two and tried the product for 60 days. Of course, nothing is stopping you from trying it, stopping it if you don’t like it, and still sending in those empty containers for your money back after the 60 days are up. Mostly-botanical formula should be safe for sensitive skin Can be used as an arousal gel and personal lubricant L-arginine can trigger herpes flare-ups A separate product from the pill for low libido that bears the same name, HerSolution Gel may help with some of the physical issues associated with arousal. This water-based gel can be used to increase vaginal lubrication and promote physical arousal through the inclusion of L-arginine. The active ingredients in HerSolution Gel include: L-arginine, a precursor of nitric oxide, may help dilate blood vessels and stimulate blood flow.10 Aloe, shea, and cocoa butter can provide additional vaginal lubrication.

• Some pills contain pheromones to attract sexual interest instantly.
• Certain vitamins, like B6 and B12, may improve mood and vitality quickly.
• Nitric oxide boosters can increase blood flow and arousal rapidly.
• Herbal stimulant blends are marketed for immediate mood enhancement.
• Quick-acting mood enhancers include L-arginine supplements.
• Aromatherapy sprays claim to set a sensual mood instantly.